Our awareness of space can be diminished.
The worse sickness I can think of is severe vertigo. Menier's Disease, for example, causes severe vertigo, and for anyone who has suffered it, the coordinates of space seem to disappear.
How precious, then, is the neural infra structure in the vestibular, kinesthetic, tactile, visual and even the auditory modalities with all their perceptual processes that transduce, interpret and integrate the information so we can know where we are in space...and subsequently, where all other things are relative to us!
As you can imagine, an infra structure as complex as this has much opportunity for a processes here or there to fail. The result is not a total chaos but diminished awareness of our coordinates.
This may present no serous problem to us when coping with the real world, but when we enter the virtual world of symbols, serious difficulties can arise.