1.
The
two main classes of immune response 24-2
2.
Human
lymphoid organs fig 24-3
3.
Figure 43.8 The
development of lymphocytes
4.
White blood cells:
Granulocytes: all have myeloperoxidase
Neutrophils: seek out and
kill bacteria; monocytes also- inflammatory response 6 hr half-life
Eosinophils-plentiful in
allergy- block some effects of mast cells
Basophils- contain heparin
and histamine . Heparin is cofactor for lipoprotein lipase, fat metabolism
5.
B-cell to pl;asma cell Fig22-17 Devel Biol
6.
Development
and activation of T cells 24-6
7.
EM
of resting and activated lymphocytes 24-7
8.
The clonal selection theory 24-8
9.
Induction
of tolerance to self antigens in lymphoid organs-alter receptor of B cell by
reactivation 24-13
10.
Exposed
lymphocytes either proliferate if signal, or degenerate or apoptosis if no
helper cell 24-13
11.
B-celll
activation by antigen fitting receptor 24-17
12.
The
hinge region is flexible and improves efficiency of binding 24-20
13.
Antibody
molecules have four chains-2 identical light, 2 identical heavy chains 24-21
14.
Stages
of B-cell development 24-22
15.
Gene
Structure for Light and Heavy Chains-constant and Variable Regions 24-30
16.
Protein
structure of antibody 24-31
17. There are non-coding
regions in the genes 24-33
18.
Clonal
selection:
1. B cells are
committed to antibody production in absence of antigen
2. each B cell is committed to produce one species of antibody (an antigen can
be recognized by different epitopes and different B cells). DNA rearrangement
is involved.
3. antibody production follows selection of B cells by antigen-become plasma
cells
4. imm memory provides long-term immunity
tolerance provides protection against autoimmune reactions to self-proteins
19.
Experiment
Showing Reorganization Within Gene During B Cell Development 24-36
20.
V-J
joining process in kappa light chain 24-37
21.
The
heavy chain VDJC segments:V segments moved next to random D, moved next to J,
moved next to C fig 24-38
22.
http://press2.nci.nih.gov/sciencebehind/immune/immune13.htm
23.
Gene-pool
selection during development 24-40
24.
Making
a clone from antigen signal 24-68
25.
Switch
sequences in constant region to make different kinds of antibodies 24-41
26.
Table 43.1 The Five
Classes of Immunoglobulins
27.
T
cell receptor heterodimer
28.
Dendritic
cell in lymph node-antigen presenting cell to T cells
29.
Figure 43.10 An
overview of the immune responses (Layer 4)
30.
Figure 43.11 The
central role of helper T cells: a closer look
31.
Figure 43.12a The
functioning of cytotoxic T cells
32.
Figure 43.12b A
cytotoxic T cell has lysed a cancer cell
33.
Figure 43.13 Humoral
response to a T-dependent antigen (Layer 3)
34.
Three
types of proteins on T-cells Fig 24-44
35.
Recognition
of foreign peptides bound to MHC24-48
36.
Class
I MHC 24-49
37.
Class
II MHC 24-49
38.
Cd8
and CD4 coreceptors on T cells-24-55
39.
Preparation
of Viral Protein Fragments for Presentation to killerT Cell by Non-immune Cell
Fig 24-58
40.
Processing
of antigen-presenting cell for presentation to helper cell
41.
Fig
24-60
42.
Thymus
selection of T-cells, sort to CD4 and CD8 Fig 24-61
43.
Fig
24-70