1.
Figure
43.5 A simplified view of the
inflammatory response
2.
Fig
24-67 interferon
3.
Fig
13-16 HIV infection
4.
Fig
19-2
5.
Fig
19-3
6.
19-7
7.
19-8
8.
19-9
9.
Cadherins
and neural tube formation
10.
19-25
E-CAM is in epidermis, NCAM in nervous system when neural plate sinks inside
11.
19-10
Adhesion belts are associated with actin filaments inside
12.
19-11
Desmosomes have cadherins outside and intermediate filaments inside
13.
19-12
Integrins can stick to extracellular matrix and to actin inside through actinin
or talin or filamin intermediate
14.
19-19
Junctional complexes between cells and cells with ECM of basal lamina
15.
Function
of different types of adhesion junctions
16.
19-23
Changes in adhesive molecules allow neural crest migration and stop
17.
Table
19-3 Members of the cadherens family are in different tissues:Ecadherin,
Ncadherin, Pcadherin, Vecadherin ,Tcadherin, protocadherin
18.
19-24
Cadherin dimers bind calcium outside the cell
19.
19-24
Cadherin dimers on one cell associate homophilically with dimer on other cell
in presence of calcium
20.
19-26
Types of binding between adhesion molecules
21.
19-27
Cell sorting relies on homophilic binding between cadherins of similar cells
and heterophilic binding with cells covering other cells
22.
Fig
19-28 Ecadherin is found at borders between fore- and midbrain and hindbrain. R
cadherin is found in forebrain and border with midbrain and in floor of
hindbrain; cadherin6 is found in different parts of forebrain and floor of
midbrain. Variable and constant regions in the gene together form the different
types of protocadherins
23.
Fig
19-29 Catenins bind to cadherins on their cytoplasmic domains
24.
Fig
19-31 CAMs are members of immunoglobulin-like family, homophilic, bind to PI
anchor inside and have fibronectin binding regions on outside
25.
Fig
19-32There are non-junctional types of adhesion mechanisms- not desmosomes,etc;
cadherins, CAMs, integrins, selectins
26.
IgCAM molecules:CD2, CD4,
CD8, C-CAM, F11, ICAM-1,2, L1, LFA-3, MAG, NCAM, NEUROFASCIN, PECAM,
TAG-1,VCAM-1
27.
cadherins
28.
Beta-catenin
control of genes
29.
Integrins-fibronectin
receptors,GPII,laminin receptor, LFA,MAC1,vitronectin,very early antigen
30.
Ligands and CAM
31.
cartilage
32.
Proteoglycans
and binding to ECM
33.
Fig
19-47 Collagen made in ER-Golgi, then buds off in secretory granule
34.
Fig
19-47After secretion it is assembled into fibrils
35.
Fig
19-53 Fibronectin is secreted, has binding domains for heparin, collagen,
cells, itself
36.
Fig
19-54 Fibronectin is distributed on the outside in a pattern similar to the
actin pattern inside
37.
Fig
19-55 Basal lamina is important for formation of all epithelium and connective
tissue is outside that
38.
Fig
19-56
39.
Fig
19-58 Basal lamina contains many proteins-laminin, collagen, these bind to
integrins on cells
40.
Fig
19-64 Divalent cations are important for cells binding to ECM by integrins
41.
Cell
adhesion promotes cell asymmetry
42.
In summary, it is clear that apical and basolateral membrane are sorted
in the TGN
Apical
membrane proteins only on free surface
43.
The requirement for spatial cues at the cell surf ace for the biogenesis
of epithelial cell polarity
44.
Ecadherin/catenin complexes attach to actin filaments
Stages of
basolateral membrane adhesion
45.
Vesicle
docking complex
46.
Table
19-3
47.
Figure 13.33 Differential
Repulsion of Temporal Retinal Ganglion
Axons on Tectal Membranes
48.
Figure 13.34(1) Differential
Retinotectal Adhesion Is Guided by Gradients
of Eph Receptors and their Ligands
49.
PATTERN
GENERATION P.444
50.
Axon
guidance
51.
Figure 13.28(1) Differentiation
of a Motor Neuron Synapse with a Muscle
52.
Figure 13.28(2) Differentiation
of a Motor Neuron Synapse with a Muscle
53.
Figure 13.28(3) Differentiation
of a Motor Neuron Synapse with a Muscle
54.
Figure 13.5(3) Segmental
Restriction of Neural Crest Cells and Motor Neurons by the Ephrin Proteins of
the Sclerotome
55.